Delivery of therapeutics to posterior eye segment: cell-encapsulating systems

Delivery of therapeutics to posterior eye segment: cell-encapsulating systems

Drug delivery for posterior segment eye disease.

In recent years, significant advances have been made in optimizing the delivery of drugs to target tissues within the eye and in maintaining effective drug doses within those tissues. Most pharmacologic management of ocular disease, however, continues to use the topical application of solutions to the surface of the eye as drops. Factors that can limit the usefulness of topical drug application...

review of intravitreal implants for extended drug delivery to the posterior segment of the eye

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...

Ultrasound-mediated transscleral delivery of macromolecules to the posterior segment of rabbit eye in vivo.

PURPOSE This study aims to determine the in vivo effectiveness of low-frequency ultrasound in mediating the transport of macromolecules to the posterior segment of the eye via transscleral route. It investigates if damage is caused by ultrasound at the tested operation parameters on the posterior ocular tissues and visual function. METHODS Ultrasound (I(SATA) = 0.12 W/cm(2), center frequency ...

Delivery of Topically Applied Calpain Inhibitory Peptide to the Posterior Segment of the Rat Eye

We developed an inhibitory peptide that specifically acts against mitochondrial μ-calpain (Tat-μCL, 23 amino acid, 2857.37 Da) and protects photoreceptors in retinal dystrophic rats. In the present study, we topically administered Tat-μCL to the eyes of Sprague-Dawley rats for 7 days to determine both the delivery route of the peptide to the posterior segment of the eye and the kinetics after t...